Pigment epithelium-derived factor promotes peritoneal dissemination of ovarian cancer through induction of immunosuppressive macrophages

Sayaka Ueno; Tamotsu Sudo; Hideyuki Saya; Eiji Sugihara

doi:10.1038/s42003-022-03837-4

Communications Biology (Sep 2022)

Pigment epithelium-derived factor promotes peritoneal dissemination of ovarian cancer through induction of immunosuppressive macrophages

Sayaka Ueno,
Tamotsu Sudo,
Hideyuki Saya,
Eiji Sugihara

Affiliations

Sayaka Ueno: Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
Tamotsu Sudo: Section of Translational Research, Hyogo Cancer Center
Hideyuki Saya: Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
Eiji Sugihara: Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine

DOI: https://doi.org/10.1038/s42003-022-03837-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

Read online

Endogenously expressed pigment epithelium–derived factor (PEDF) promotes increased survival of ovarian cancer cells in the peritoneal cavity by inducing IL-10 expression in CD206 + peritoneal macrophages.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal