Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques

Zhen Yang; Zhen Yang; Zhen Yang; Zhen Yang; Junhe Shi; Junhe Shi; Junhe Shi; Li Chen; Li Chen; Li Chen; Li Chen; Changgeng Fu; Dazhuo Shi; Dazhuo Shi; Dazhuo Shi; Dazhuo Shi; Hua Qu; Hua Qu; Hua Qu

doi:10.3389/fcell.2022.811196

Frontiers in Cell and Developmental Biology (Feb 2022)

Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques

Zhen Yang,
Zhen Yang,
Zhen Yang,
Zhen Yang,
Junhe Shi,
Junhe Shi,
Junhe Shi,
Li Chen,
Li Chen,
Li Chen,
Li Chen,
Changgeng Fu,
Dazhuo Shi,
Dazhuo Shi,
Dazhuo Shi,
Dazhuo Shi,
Hua Qu,
Hua Qu,
Hua Qu

Affiliations

Zhen Yang: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Zhen Yang: Cardiovascular Department, Peking University Traditional Chinese Medicine Clinical Medical School (Xiyuan), Beijing, China
Zhen Yang: Academy of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China
Zhen Yang: National Clinical Research Center for Chinese Medicine Cardiology, Beijing, China
Junhe Shi: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Junhe Shi: National Clinical Research Center for Chinese Medicine Cardiology, Beijing, China
Junhe Shi: NMPA Key Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine, Beijing, China
Li Chen: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Li Chen: Cardiovascular Department, Peking University Traditional Chinese Medicine Clinical Medical School (Xiyuan), Beijing, China
Li Chen: Academy of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China
Li Chen: National Clinical Research Center for Chinese Medicine Cardiology, Beijing, China
Changgeng Fu: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Dazhuo Shi: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Dazhuo Shi: Cardiovascular Department, Peking University Traditional Chinese Medicine Clinical Medical School (Xiyuan), Beijing, China
Dazhuo Shi: Academy of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China
Dazhuo Shi: National Clinical Research Center for Chinese Medicine Cardiology, Beijing, China
Hua Qu: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Hua Qu: National Clinical Research Center for Chinese Medicine Cardiology, Beijing, China
Hua Qu: NMPA Key Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine, Beijing, China

DOI: https://doi.org/10.3389/fcell.2022.811196
Journal volume & issue: Vol. 10

Abstract

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Pyroptosis is a special way of programmed cell death which is dependent on the activation of cysteinyl aspartate specific proteinase 1 (Caspase-1) and Caspase-4/5/11. Ferroptosis is an iron-dependent cell death that characterized by the intra-cellular lipid peroxidation-mediated membrane damage. Pyroptosis or ferroptosis in macrophages, smooth muscle cells, and vascular endothelial cells are believed to be closely related to the progression of atherosclerotic plaques. Therefore, we discuss the role of pyroptosis and ferroptosis in the development of atherosclerotic plaques and may provide new strategies for the treatment of atherosclerosis.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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