Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis

Bowen Zhan; Yanqing Gao; Wenqing Gao; Ye Li; Zhengyang Li; Qi Qi; Xin Lan; Hongbo Shen; Jianhua Gan; Guoping Zhao; Jixi Li

doi:10.1038/s42003-022-04019-y

Communications Biology (Oct 2022)

Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis

Bowen Zhan,
Yanqing Gao,
Wenqing Gao,
Ye Li,
Zhengyang Li,
Qi Qi,
Xin Lan,
Hongbo Shen,
Jianhua Gan,
Guoping Zhao,
Jixi Li

Affiliations

Bowen Zhan: State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University
Yanqing Gao: State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University
Wenqing Gao: State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University
Ye Li: State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University
Zhengyang Li: State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University
Qi Qi: State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University
Xin Lan: State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University
Hongbo Shen: Shanghai Clinical Research Center for Infectious Disease (tuberculosis), Shanghai Pulmonary Hospital, Tongji University School of Medicine
Jianhua Gan: State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University
Guoping Zhao: Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences
Jixi Li: State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University

DOI: https://doi.org/10.1038/s42003-022-04019-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Crystal structures of M. tuberculosis elongation factors EF-Tu and EF-Ts in complex and GDP-bound Ef-Tu reveal the molecular basis of EF-Tu’s representative recycling and inactive forms in protein translation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal