The CXCL10/CXCR3 axis in acute respiratory distress syndrome

Abstract

The CXC chemokine ligand-10/CXC receptor-3 (CXCL10/CXCR3) axis, a crucial pathway mediating Th1-type immunity, substantially contributes to the development of acute respiratory distress syndrome(ARDS) by enhancing inflammatory storms. It additionally promotes vascular endothelial apoptosis and impedes vasculature repair, elevating the risk of pulmonary vascular thrombosis. Conversely, this axis plays a protective role in limiting extra-cellular matrix deposition and modulating cell migration, thereby mitigating pulmonary fibrosis. The various mechanisms of the CXCL10/CXCR3 axis in the pathogenesis and progression of ARDS could offer novel insights for the diagnosis and treatment of ARDS.

Keywords

• cxcl10/cxcr3 axis|acute respiratory distress syndrome|inflammations|pulmonary embolism|pulmonary fibrosis