Compartmental and Data-Based Modeling of Cerebral Hemodynamics: Linear Analysis

Abstract

Compartmental and data-based modeling of cerebral hemodynamics are alternative approaches that utilize distinct model forms and have been employed in the quantitative study of cerebral hemodynamics. This paper examines the relation between a compartmental equivalent circuit and a data-based input-output model of dynamic cerebral autoregulation (DCA) and dynamic CO2-vasomotor reactivity (DVR). The compartmental model is constructed as an equivalent circuit utilizing putative first principles and previously proposed hypothesis-based models. The linear input-output dynamics of this compartmental model are compared with the data-based estimates of the DCA-DVR process. This comparative study indicates that there are some qualitative similarities between the two-input compartmental model and experimental results.

Keywords

• Cerebral autoregulation
• compartmental modeling
• nonparametric modeling
• vasomotor reactivity