Conformational pathway provides unique sensitivity to a synaptic mGluR

Chris H. Habrian; Joshua Levitz; Vojtech Vyklicky; Zhu Fu; Adam Hoagland; Isabelle McCort-Tranchepain; Francine Acher; Ehud Y. Isacoff

doi:10.1038/s41467-019-13407-8

Nature Communications (Dec 2019)

Conformational pathway provides unique sensitivity to a synaptic mGluR

Chris H. Habrian,
Joshua Levitz,
Vojtech Vyklicky,
Zhu Fu,
Adam Hoagland,
Isabelle McCort-Tranchepain,
Francine Acher,
Ehud Y. Isacoff

Affiliations

Chris H. Habrian: Biophysics Graduate Group, University of California
Joshua Levitz: Department of Molecular and Cell Biology, University of California
Vojtech Vyklicky: Department of Molecular and Cell Biology, University of California
Zhu Fu: Department of Molecular and Cell Biology, University of California
Adam Hoagland: Department of Molecular and Cell Biology, University of California
Isabelle McCort-Tranchepain: Paris Descartes University
Francine Acher: Paris Descartes University
Ehud Y. Isacoff: Biophysics Graduate Group, University of California

DOI: https://doi.org/10.1038/s41467-019-13407-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate response of an mGluR.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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