Nature Communications (Mar 2020)

Degree and site of chromosomal instability define its oncogenic potential

  • Wilma H. M. Hoevenaar,
  • Aniek Janssen,
  • Ajit I. Quirindongo,
  • Huiying Ma,
  • Sjoerd J. Klaasen,
  • Antoinette Teixeira,
  • Bastiaan van Gerwen,
  • Nico Lansu,
  • Folkert H. M. Morsink,
  • G. Johan A. Offerhaus,
  • René H. Medema,
  • Geert J. P. L. Kops,
  • Nannette Jelluma

DOI
https://doi.org/10.1038/s41467-020-15279-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely dependent on both its extent and anatomical location.