Alcoholic liver disease and mast cells: What's your gut got to do with it?

Julie Ann Tolefree; Abigail Joy Garcia; Jenee Farrell; Vik Meadows; Lindsey Kennedy; Laura Hargrove; Jennifer Demieville; Nicole Francis; Julia Mirabel; Heather Francis

Liver Research (Mar 2019)

Alcoholic liver disease and mast cells: What's your gut got to do with it?

Julie Ann Tolefree,
Abigail Joy Garcia,
Jenee Farrell,
Vik Meadows,
Lindsey Kennedy,
Laura Hargrove,
Jennifer Demieville,
Nicole Francis,
Julia Mirabel,
Heather Francis

Affiliations

Julie Ann Tolefree: Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, TX, USA
Abigail Joy Garcia: Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, TX, USA
Jenee Farrell: Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, TX, USA
Vik Meadows: Division of Research, Central Texas Veterans Health Care System, Temple, TX, USA; Department of Medicine, Indiana University, Indianapolis, IN, USA
Lindsey Kennedy: Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, TX, USA; Department of Medicine, Indiana University, Indianapolis, IN, USA
Laura Hargrove: Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, TX, USA
Jennifer Demieville: Division of Research, Central Texas Veterans Health Care System, Temple, TX, USA
Nicole Francis: Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, TX, USA
Julia Mirabel: Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, TX, USA
Heather Francis: Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, TX, USA; Division of Research, Central Texas Veterans Health Care System, Temple, TX, USA; Department of Medicine, Indiana University, Indianapolis, IN, USA; Corresponding author. Department of Medicine, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN, USA.

Journal volume & issue: Vol. 3, no. 1
pp. 46 – 54

Abstract

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Alcoholic liver disease (ALD) remains one of the leading causes of liver injury and death when left untreated. The gut microbiota has been recognized as a key regulator of a number of pathologies, including ALD. The role of mast cells (MCs) during liver disease progression has been demonstrated in a number of animal models and in human liver diseases. The interaction between the gut microbiota and MCs has been investigated, and links between the gut and these immune cells are being uncovered. The interplay between the gut microbiota and MCs during ALD has been evaluated and studies suggest that there could be an important link between MCs, their mediators and gut inflammation during the progression of ALD. Keywords: Alcoholic liver disease (ALD), Alcoholic steatohepatitis (ASH), Cirrhosis, Steatosis, Mast cells (MCs), Microbiota, Gut

Published in Liver Research

ISSN: 2096-2878 (Print); 2542-5684 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.keaipublishing.com/en/journals/liver-research/

About the journal