Nature Communications (May 2017)

Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

  • Justin J. -L. Wong,
  • Dadi Gao,
  • Trung V. Nguyen,
  • Chau-To Kwok,
  • Michelle van Geldermalsen,
  • Rob Middleton,
  • Natalia Pinello,
  • Annora Thoeng,
  • Rajini Nagarajah,
  • Jeff Holst,
  • William Ritchie,
  • John E. J. Rasko

DOI
https://doi.org/10.1038/ncomms15134
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Intron retention is a conserved mechanism that controls gene expression but its regulation is poorly understood. Here, the authors provide evidence that DNA methylation regulates intron retention and find reduced MeCP2 occupancy and splicing factor recruitment near affected splice junctions.