Research Progress of PDGF Promoting Wound Repair

Abstract

Platelet-derived growth factor (PDGF), a multi-potent cytokine, has caught attention in the field of wound repair. The PDGF ability to initiate cell proliferation, migration, secretion and promote angiogenesis can be beneficial for wound healing. Platelet-rich plasma and recombinant human PDGF that contain high concentrations of PDGF have been used for decades in wound repair. However, their short shelf life, limited allogenic use, low bioavailability, and many side effects make them unable to meet clinical needs. Optimized platelet-rich fibrin and concentrated growth factor have higher concentrations of PDGF and better wound repair ability. Platelet lysate, with the ability to significantly extend the preservation period and reduce the risk of allogeneic use, has become the development direction for platelet wound repair. The high-energy delivery system based on bioengineering technology can significantly improve the local resident rate and prolong the action time of PDGF. A variety of transformed PDGF capable of inducing sustained tonic signals can be created through the modification of PDGF structure and addition of active domains. Functional controllable PDGF simulation peptides can be generated by integrating the active domains and a variety of efficient PDGF gene delivery strategies can be derived, thus providing more potential options to solve the problem of wound repair. The focus of this article, is on reviewing the physiological and applied.

Keywords

• platelet-derived growth factor
• wound repair
• applied research