Encapsulation of Imazalil in HKUST-1 with Versatile Antimicrobial Activity

Hongqiang Dong; Yuke He; Chen Fan; Zhongqiang Zhu; Chunrong Zhang; Xinju Liu; Kun Qian; Tao Tang

doi:10.3390/nano12213879

Nanomaterials (Nov 2022)

Encapsulation of Imazalil in HKUST-1 with Versatile Antimicrobial Activity

Hongqiang Dong,
Yuke He,
Chen Fan,
Zhongqiang Zhu,
Chunrong Zhang,
Xinju Liu,
Kun Qian,
Tao Tang

Affiliations

Hongqiang Dong: College of Agriculture, Tarim University, Alaer 843300, China
Yuke He: College of Plant Protection, Southwest University, Chongqing 400716, China
Chen Fan: Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Technology and Business University, Beijing 100048, China
Zhongqiang Zhu: College of Agriculture, Tarim University, Alaer 843300, China
Chunrong Zhang: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture and Rural Affairs, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China
Xinju Liu: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture and Rural Affairs, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China
Kun Qian: College of Plant Protection, Southwest University, Chongqing 400716, China
Tao Tang: State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture and Rural Affairs, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

DOI: https://doi.org/10.3390/nano12213879
Journal volume & issue: Vol. 12, no. 21
p. 3879

Abstract

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Based on high surface areas, adjustable porosity and microbicide activity, metal-organic frameworks (MOFs) HKUST-1 are widely used as drug release carriers for their slow degradation characteristics under slightly acidic conditions. In this work, porous HKUST-1 was reacted rapidly by cholinium salt (as the deprotonation agent and template) in an aqueous solution at room temperature. A novel antimicrobial system based on an imazalil encapsulated metal organic framework (imazalil IL-3@HKUST-1) was established. Imazalil IL-3@HKUST-1 could achieve synergism in inhibiting pathogenic fungi and bacteria. Moreover, six days after treatment, the slow and constant release of imazalil from imazalil IL@HKUST-1 exhibited better sustainability and microbicidal activity than imazalil. We believe that the method may provide a new strategy for related plant diseases caused by bacteria or fungi.

Published in Nanomaterials

ISSN: 2079-4991 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: https://www.mdpi.com/journal/nanomaterials

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