Autoimmune pulmonary alveolar proteinosis presenting as localized multifocal GGOs: A case report

Koichi Honda, MD; Hirofumi Koike, MD; Shin Tsutsui, MD; Ryo Toya, MD; Keitaro Matsumoto, MD; Shinji Okano, MD; Hirokazu Taniguchi, MD; Kazuto Ashizawa, MD

Radiology Case Reports (Dec 2024)

Autoimmune pulmonary alveolar proteinosis presenting as localized multifocal GGOs: A case report

Koichi Honda, MD,
Hirofumi Koike, MD,
Shin Tsutsui, MD,
Ryo Toya, MD,
Keitaro Matsumoto, MD,
Shinji Okano, MD,
Hirokazu Taniguchi, MD,
Kazuto Ashizawa, MD

Affiliations

Koichi Honda, MD: Department of Clinical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki 852-8501, Japan
Hirofumi Koike, MD: Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki 852-8501, Japan; Corresponding author.
Shin Tsutsui, MD: Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki 852-8501, Japan
Ryo Toya, MD: Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki 852-8501, Japan
Keitaro Matsumoto, MD: Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki 852-8501, Japan
Shinji Okano, MD: Department of Pathology, Nagasaki University Hospital, Sakamoto, Nagasaki 852-8501, Japan
Hirokazu Taniguchi, MD: Clinical Oncology Center, Nagasaki University Hospital, Sakamoto, Nagasaki 852-8501, Japan
Kazuto Ashizawa, MD: Department of Clinical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki 852-8501, Japan; Clinical Oncology Center, Nagasaki University Hospital, Sakamoto, Nagasaki 852-8501, Japan

Journal volume & issue: Vol. 19, no. 12
pp. 6072 – 6075

Abstract

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Pulmonary alveolar proteinosis (PAP) is a rare disease, which is characterized by the alveolar accumulation of surfactant. A crazy-paving appearance on chest thin-section computed tomography (TSCT) is a characteristic feature of this disease. We report an unusual case of PAP, which presented as multiple localized ground glass opacites (GGOs) on TSCT in an 80-year-old female. As one of these lesions at the apex of the right lung increased in size, it was suspected to be a pulmonary adenocarcinoma. However, the others became smaller during the follow-up period. Right upper lobectomy was performed, and PAP was histologically diagnosed. In cases exhibiting multiple localized GGOs, PAP should be considered, even if GGOs with a crazy-paving-like appearance are distributed in a lobular rather than diffuse manner.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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