Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production
Chi-I Chang,
Chien-Chih Chen,
Che-Yi Chao,
Sheng-Yang Wang,
Hsun-Shuo Chang,
Ping-Jyun Sung,
Guan-Jhong Huang,
Yen-Cheng Li,
Yueh-Hsiung Kuo
Affiliations
Chi-I Chang
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
Chien-Chih Chen
Department of Biotechnology, Hungkuang University, Taichung 443, Taiwan
Che-Yi Chao
Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan
Sheng-Yang Wang
Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan
Hsun-Shuo Chang
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Ping-Jyun Sung
Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Guan-Jhong Huang
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Yen-Cheng Li
Department of Chemistry, National Taiwan University, Taipei 106, Taiwan
Yueh-Hsiung Kuo
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Three new sesquiterpenoids, 2α-hydroxy-3,3,6α,9β-tetramethyltricyclo[4,3,21,4]undecane (1), 11-acetoxyeudesman-4β-ol (4), and 2α,3β-dihydroxy-4β-methyl-6,8,10-cadinatriene (6), four known sesquiterpenoids (2, 3, 5, and 7), together with eight known diterpenoids (8–15), were isolated from the wood of Cunninghamia konishii. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. Four sesquiterpenoids (1, 4, 5, and 6) and all the diterpenoids (8–15) were evaluated for inhibition of nitric oxide production in lipopolysaccharides (LPS)-activated RAW 264.7 macrophages and the results showed that compounds 10 and 15 exhibited moderate inhibitory activities against nitric oxide production.
