Synthetic protein-conductive membrane nanopores built with DNA

Tim Diederichs; Genevieve Pugh; Adam Dorey; Yongzheng Xing; Jonathan R. Burns; Quoc Hung Nguyen; Marc Tornow; Robert Tampé; Stefan Howorka

doi:10.1038/s41467-019-12639-y

Nature Communications (Nov 2019)

Synthetic protein-conductive membrane nanopores built with DNA

Tim Diederichs,
Genevieve Pugh,
Adam Dorey,
Yongzheng Xing,
Jonathan R. Burns,
Quoc Hung Nguyen,
Marc Tornow,
Robert Tampé,
Stefan Howorka

Affiliations

Tim Diederichs: Institute of Biochemistry, Biocenter, Goethe University Frankfurt
Genevieve Pugh: Department of Chemistry, Institute of Structural Molecular Biology, University College London
Adam Dorey: Department of Chemistry, Institute of Structural Molecular Biology, University College London
Yongzheng Xing: Department of Chemistry, Institute of Structural Molecular Biology, University College London
Jonathan R. Burns: Department of Chemistry, Institute of Structural Molecular Biology, University College London
Quoc Hung Nguyen: Molecular Electronics, Technical University of Munich
Marc Tornow: Molecular Electronics, Technical University of Munich
Robert Tampé: Institute of Biochemistry, Biocenter, Goethe University Frankfurt
Stefan Howorka: Department of Chemistry, Institute of Structural Molecular Biology, University College London

DOI: https://doi.org/10.1038/s41467-019-12639-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Nanopores have a wide range of applications in the field of sensing. Here the authors report on synthetic nanopores made of DNA and designed for the transit of folded proteins across membranes to allow for biosensing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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