Therapeutics and Clinical Risk Management (May 2016)
Recovery of a 10-year-old girl from methicillin-resistant Staphylococcus aureus sepsis in response to low-dose ceftaroline treatment
Abstract
Stefan Borgmann,1 Beate Rieß,1 Thomas von Wernitz-Keibel,2 Matthias Bühler,3 Franziska Layer,4 Birgit Strommenger4 1Department of Infectious Diseases and Infection Control, 2Department of Anaesthesiology and Intensive Care Medicine, 3Department of Trauma Surgery, Klinikum Ingolstadt, Ingolstadt, 4National Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department for Infectious Diseases, Robert Koch Institute, Wernigerode Branch, Wernigerode, Germany Abstract: A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. Various bacterial species were isolated from multiple wounds, and methicillin-resistant Staphylococcus aureus (MRSA) was one among them. After the amputation of her lower legs, she developed MRSA sepsis, which was successfully treated with a relatively low dosage of ceftaroline (Zinforo®/Teflaro®; 2×9 mg/kg/d), although the bacterial isolate’s minimal inhibitory concentration (1.5–4 mg/L) suggested a decreased susceptibility. In summary, ceftaroline was highly efficient and well tolerated by the patient suffering from MRSA sepsis. Keywords: side effects, susceptibility, ceftaroline, minimal inhibitory concentration, therapy
