Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

Ursula K. Rohlwink; Anthony Figaji; Katalin A. Wilkinson; Stuart Horswell; Abdul K. Sesay; Armin Deffur; Nico Enslin; Regan Solomons; Ronald Van Toorn; Brian Eley; Michael Levin; Robert J. Wilkinson; Rachel P. J. Lai

doi:10.1038/s41467-019-11783-9

Nature Communications (Aug 2019)

Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

Ursula K. Rohlwink,
Anthony Figaji,
Katalin A. Wilkinson,
Stuart Horswell,
Abdul K. Sesay,
Armin Deffur,
Nico Enslin,
Regan Solomons,
Ronald Van Toorn,
Brian Eley,
Michael Levin,
Robert J. Wilkinson,
Rachel P. J. Lai

Affiliations

Ursula K. Rohlwink: Neuroscience Institute, Division of Neurosurgery, University of Cape Town
Anthony Figaji: Neuroscience Institute, Division of Neurosurgery, University of Cape Town
Katalin A. Wilkinson: Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
Stuart Horswell: The Francis Crick Institute
Abdul K. Sesay: The Francis Crick Institute
Armin Deffur: Department of Medicine, University of Cape Town
Nico Enslin: Neuroscience Institute, Division of Neurosurgery, University of Cape Town
Regan Solomons: Department of Paediatrics and Child Health, Stellenbosch University
Ronald Van Toorn: Department of Paediatrics and Child Health, Stellenbosch University
Brian Eley: Paediatric Infectious Diseases Unit, Department of Paediatrics and Child Health, University of Cape Town
Michael Levin: Department of Infectious Disease, Imperial College London
Robert J. Wilkinson: Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
Rachel P. J. Lai: The Francis Crick Institute

DOI: https://doi.org/10.1038/s41467-019-11783-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

Read online

Tuberculosis meningitis (TBM) is a severe form of TB with limited treatment options. Here, the authors perform RNA sequencing on whole blood and on ventricular and lumbar cerebrospinal fluid (CSF) samples from pediatric patients treated for TBM to characterize the immune response and tissue damage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal