Spatiotemporal patterns of sleep spindle activity in human anterior thalamus and cortex
Hannah Bernhard,
Frederic L.W.V.J. Schaper,
Marcus L.F. Janssen,
Erik D. Gommer,
Bernadette M. Jansma,
Vivianne Van Kranen-Mastenbroek,
Rob P.W. Rouhl,
Peter de Weerd,
Joel Reithler,
Mark J. Roberts,
Louis G. Wagner,
Albert J. Colon,
Danny M.W. Hilkmann,
Marielle C.G. Vlooswijk,
Jeske Nelissen,
Linda Ackermans,
Yasin Temel
Affiliations
Hannah Bernhard
Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands; Centre for Integrative Neuroscience, Maastricht University, Maastricht, The Netherlands; Corresponding author: Department of Cognitive Neuroscience, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
Frederic L.W.V.J. Schaper
Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Center for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's hospital, Harvard Medical School, Boston, United States
Marcus L.F. Janssen
School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, the Netherlands
Erik D. Gommer
Academic Center for Epileptology Kempenhaeghe/MUMC+ Maastricht and Heeze, the Netherlands; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, the Netherlands
Bernadette M. Jansma
Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands; Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, the Netherlands
Vivianne Van Kranen-Mastenbroek
Academic Center for Epileptology Kempenhaeghe/MUMC+ Maastricht and Heeze, the Netherlands; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, the Netherlands
Rob P.W. Rouhl
Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands; Academic Center for Epileptology Kempenhaeghe/MUMC+ Maastricht and Heeze, the Netherlands; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
Peter de Weerd
Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands; Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, the Netherlands
Joel Reithler
Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands; Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, the Netherlands
Mark J. Roberts
Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands; Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, the Netherlands
Louis G. Wagner
Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands; Academic Center for Epileptology Kempenhaeghe/MUMC+ Maastricht and Heeze, the Netherlands
Albert J. Colon
Academic Center for Epileptology Kempenhaeghe/MUMC+ Maastricht and Heeze, the Netherlands
Danny M.W. Hilkmann
Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, the Netherlands
Marielle C.G. Vlooswijk
Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands
Jeske Nelissen
Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands
Linda Ackermans
Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands; Academic Center for Epileptology Kempenhaeghe/MUMC+ Maastricht and Heeze, the Netherlands
Yasin Temel
Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands; European Graduate School of Neuroscience (EURON), Maastricht University, Maastricht, the Netherlands
Sleep spindles (8 - 16 Hz) are transient electrophysiological events during non-rapid eye movement sleep. While sleep spindles are routinely observed in the cortex using scalp electroencephalography (EEG), recordings of their thalamic counterparts have not been widely studied in humans. Based on a few existing studies, it has been hypothesized that spindles occur as largely local phenomena. We investigated intra-thalamic and thalamocortical spindle co-occurrence, which may underlie thalamocortical communication. We obtained scalp EEG and thalamic recordings from 7 patients that received bilateral deep brain stimulation (DBS) electrodes to the anterior thalamus for the treatment of drug resistant focal epilepsy. Spindles were categorized into subtypes based on their main frequency (i.e., slow (10±2 Hz) or fast (14±2 Hz)) and their level of thalamic involvement (spanning one channel, or spreading uni- or bilaterally within the thalamus). For the first time, we contrasted observed spindle patterns with permuted data to estimate random spindle co-occurrence. We found that multichannel spindle patterns were systematically coordinated at the thalamic and thalamocortical level. Importantly, distinct topographical patterns of thalamocortical spindle overlap were associated with slow and fast subtypes of spindles. These observations provide further evidence for coordinated spindle activity in thalamocortical networks.
