PIPES-ZnO NPs coupled catalyst for the synthesis of 2-((1H-indol-3-yl)(phenyl)methyl)-5,5-dimethylcyclohexane-1,3-diones

Abstract

Synthesis, characterization and catalytic application of Zinc Oxide nanoparticles (ZnO NPs) with 1,4-Piperazinediethanesulfonic acid (PIPES) have been explored as a coupled catalyst for the condensation reaction of Dimedone (1), Benzaldehyde and (2) Indole (3) in stipulated period of time to give 2-((1H-indol-3-yl)(phenyl)methyl)-5,5-dimethylcyclohexane-1,3-dione (4) under ultrasound irradiation technique at 60 °C temperature. Pharmacological importance of targeted products along with surface properties of ZnO NPs and Bronsted acidity of PIPES together became promising advantages for this protocol to establish.

Keywords

• PIPES-ZnO NPs
• Coupled catalyst
• Bronsted acidity
• Ultrasound irradiation