Nature Communications (Jun 2020)

Tracking down the molecular architecture of the synaptonemal complex by expansion microscopy

  • Fabian U. Zwettler,
  • Marie-Christin Spindler,
  • Sebastian Reinhard,
  • Teresa Klein,
  • Andreas Kurz,
  • Ricardo Benavente,
  • Markus Sauer

DOI
https://doi.org/10.1038/s41467-020-17017-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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The authors test expansion microscopy protocols for investigation of the molecular organisation of mammalian synaptonemal complexes (SCs) with structured illumination microscopy. They show that the molecular structure is preserved during expansion and ultrastructural details of SCs can be revealed.