Nature Communications (Apr 2021)
Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation
- Tomohiko Matsuo,
- Tomoko Isosaka,
- Yuichiro Hayashi,
- Lijun Tang,
- Akihiro Doi,
- Aiko Yasuda,
- Mikio Hayashi,
- Chia-Ying Lee,
- Liqin Cao,
- Natsumaro Kutsuna,
- Sachihiro Matsunaga,
- Takeshi Matsuda,
- Ikuko Yao,
- Mitsuyoshi Setou,
- Dai Kanagawa,
- Koichiro Higasa,
- Masahito Ikawa,
- Qinghua Liu,
- Reiko Kobayakawa,
- Ko Kobayakawa
Affiliations
- Tomohiko Matsuo
- Department of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University
- Tomoko Isosaka
- Department of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University
- Yuichiro Hayashi
- Department of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University
- Lijun Tang
- Department of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University
- Akihiro Doi
- Department of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University
- Aiko Yasuda
- Department of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University
- Mikio Hayashi
- Department of Cellular and Functional Biology, Institute of Biomedical Science, Kansai Medical University
- Chia-Ying Lee
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Liqin Cao
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Natsumaro Kutsuna
- Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo
- Sachihiro Matsunaga
- Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science
- Takeshi Matsuda
- Department of Optical Imaging, Institute for Medical Photonics Research, PMPERC and IMIC, Hamamatsu University School of Medicine
- Ikuko Yao
- Department of Optical Imaging, Institute for Medical Photonics Research, PMPERC and IMIC, Hamamatsu University School of Medicine
- Mitsuyoshi Setou
- Department of Cellular and Molecular Anatomy and IMIC, Hamamatsu University School of Medicine
- Dai Kanagawa
- Department of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University
- Koichiro Higasa
- Department of Genome Analysis, Institute of Biomedical Science, Kansai Medical University
- Masahito Ikawa
- Research Institute for Microbial Diseases, Osaka University
- Qinghua Liu
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Reiko Kobayakawa
- Department of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University
- Ko Kobayakawa
- Department of Functional Neuroscience, Institute of Biomedical Science, Kansai Medical University
- DOI
- https://doi.org/10.1038/s41467-021-22205-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Matsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long time survival in a lethal hypoxic environment.
