Nature Communications (Jun 2020)
A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region
- Jean Claude Semuto Ngabonziza,
- Chloé Loiseau,
- Michael Marceau,
- Agathe Jouet,
- Fabrizio Menardo,
- Oren Tzfadia,
- Rudy Antoine,
- Esdras Belamo Niyigena,
- Wim Mulders,
- Kristina Fissette,
- Maren Diels,
- Cyril Gaudin,
- Stéphanie Duthoy,
- Willy Ssengooba,
- Emmanuel André,
- Michel K. Kaswa,
- Yves Mucyo Habimana,
- Daniela Brites,
- Dissou Affolabi,
- Jean Baptiste Mazarati,
- Bouke Catherine de Jong,
- Leen Rigouts,
- Sebastien Gagneux,
- Conor Joseph Meehan,
- Philip Supply
Affiliations
- Jean Claude Semuto Ngabonziza
- National Reference Laboratory Division, Department of Biomedical Services, Rwanda Biomedical Center
- Chloé Loiseau
- Swiss Tropical and Public Health Institute
- Michael Marceau
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017, CIIL - Center for Infection and Immunity of Lille
- Agathe Jouet
- Genoscreen
- Fabrizio Menardo
- Swiss Tropical and Public Health Institute
- Oren Tzfadia
- Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine
- Rudy Antoine
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017, CIIL - Center for Infection and Immunity of Lille
- Esdras Belamo Niyigena
- National Reference Laboratory Division, Department of Biomedical Services, Rwanda Biomedical Center
- Wim Mulders
- Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine
- Kristina Fissette
- Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine
- Maren Diels
- BCCM/ITM, Mycobacterial Culture Collection, Institute of Tropical Medicine
- Cyril Gaudin
- Genoscreen
- Stéphanie Duthoy
- Genoscreen
- Willy Ssengooba
- Department of Medical Microbiology, College of Health Sciences, Makerere University
- Emmanuel André
- Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology and Immunology
- Michel K. Kaswa
- National Tuberculosis Program
- Yves Mucyo Habimana
- Tuberculosis and Other Respiratory Diseases Division, Institute of HIV/AIDS Disease Prevention and Control, Rwanda Biomedical Center
- Daniela Brites
- Swiss Tropical and Public Health Institute
- Dissou Affolabi
- Laboratoire de Référence des Mycobactéries
- Jean Baptiste Mazarati
- Department of Biomedical Services, Rwanda Biomedical Center
- Bouke Catherine de Jong
- Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine
- Leen Rigouts
- Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine
- Sebastien Gagneux
- Swiss Tropical and Public Health Institute
- Conor Joseph Meehan
- Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine
- Philip Supply
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017, CIIL - Center for Infection and Immunity of Lille
- DOI
- https://doi.org/10.1038/s41467-020-16626-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to be evolved from a common progenitor in Africa. Here, the authors identify two MTBC strains isolated from patients with multidrug-resistant tuberculosis, representing an as-yet-unknown lineage further supporting an East African origin for the MTBC.
