Nature Communications (Jan 2018)

Phosphorylation-induced conformation of β2-adrenoceptor related to arrestin recruitment revealed by NMR

  • Yutaro Shiraishi,
  • Mei Natsume,
  • Yutaka Kofuku,
  • Shunsuke Imai,
  • Kunio Nakata,
  • Toshimi Mizukoshi,
  • Takumi Ueda,
  • Hideo Iwaï,
  • Ichio Shimada

DOI
https://doi.org/10.1038/s41467-017-02632-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Upon stimulation by agonist binding, the C-terminal regions of G-protein-coupled receptors (GPCRs) become phosphorylated by GPCR kinases, and phosphorylated GPCRs bind arrestin. Here the authors give structural insights into the phosphorylation induced conformational changes in GPCRs by performing NMR studies with the β2-adrenoceptor.