Nature Communications (Apr 2019)

Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace

  • Laura Jardine,
  • Sarah Wiscombe,
  • Gary Reynolds,
  • David McDonald,
  • Andrew Fuller,
  • Kile Green,
  • Andrew Filby,
  • Ian Forrest,
  • Marie-Helene Ruchaud-Sparagano,
  • Jonathan Scott,
  • Matthew Collin,
  • Muzlifah Haniffa,
  • A. John Simpson

DOI
https://doi.org/10.1038/s41467-019-09913-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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The diversity of human mononuclear phagocyte subsets remains to be characterized in many tissue-specific and functional contexts, including pulmonary inflammation. Here the authors characterize dendritic cell and monocyte subset recruitment to the bronchoalveolar space in a human LPS inhalation model.