Genetic polymorphisms of human platelet antigens in Euro-African and Japanese descendants from Parana, Southern Brazil

Abstract

The frequency distributions of HPA-1 to HPA-6 and HPA-15 were evaluated in two Brazilian populations from Parana: a mixed population of predominantly Caucasians and a population of Japanese descendants. Genotyping was performed by PCR-SSP in 364 unrelated individuals. Differences in the distribution of HPA highlight diversity in Brazilian miscegenation and the importance of formation of the HPA panel composed of regional blood donors.

Keywords

• allele frequency
• genotyping
• hpa
• polymorphisms