Magnetic black phosphorus microbubbles for targeted tumor theranostics
Zhu Yao,
Liu Yingying,
Xie Zhongjian,
He Tianzhen,
Su Lili,
Guo Fengjuan,
Arkin Gulzira,
Lai XiaoShu,
Xu Jinfeng,
Zhang Han
Affiliations
Zhu Yao
Department of Ultrasonography, Shenzhen Medical Ultrasound Engineering Center, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Clinical Medical College of Southern University of Science and Technology, Shenzhen518020, China
Liu Yingying
Department of Ultrasonography, Shenzhen Medical Ultrasound Engineering Center, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Clinical Medical College of Southern University of Science and Technology, Shenzhen518020, China
Xie Zhongjian
Shenzhen International Institute for Biomedical Research, 518116Shenzhen, Guangdong, China
He Tianzhen
Department of Ultrasonography, Shenzhen Medical Ultrasound Engineering Center, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Clinical Medical College of Southern University of Science and Technology, Shenzhen518020, China
Su Lili
Department of Ultrasonography, Shenzhen Medical Ultrasound Engineering Center, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Clinical Medical College of Southern University of Science and Technology, Shenzhen518020, China
Guo Fengjuan
Department of Ultrasonography, Shenzhen Medical Ultrasound Engineering Center, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Clinical Medical College of Southern University of Science and Technology, Shenzhen518020, China
Arkin Gulzira
Department of Ultrasonography, Shenzhen Medical Ultrasound Engineering Center, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Clinical Medical College of Southern University of Science and Technology, Shenzhen518020, China
Lai XiaoShu
Department of Ultrasonography, Shenzhen Medical Ultrasound Engineering Center, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Clinical Medical College of Southern University of Science and Technology, Shenzhen518020, China
Xu Jinfeng
Department of Ultrasonography, Shenzhen Medical Ultrasound Engineering Center, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, First Clinical Medical College of Southern University of Science and Technology, Shenzhen518020, China
Zhang Han
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, and Otolaryngology Department and Biobank of the First Affiliated Hospital, Shenzhen Second People’s Hospital, Health Science Center, Shenzhen University, Shenzhen518060, P.R. China
Black phosphorus (BP) is attracting more and more interest for the biomedical application. The absorption in a wide spectral range and high photothermal conversion efficiency make BP suitable for photothermal therapy. However, BP alone is hard to realize the targeted therapy, which limits the precision and efficiency of the therapy. Magnetic microbubbles (MBs) are favored drug carriers because they can resist the sheer force of blood flow in a magnetic field, which improves the efficiency of MBs adhesion to the vascular wall for targeted ultrasound diagnosis and therapy. This study first optimized the magnetic MBs configurations through controlling the connecting polyethylene glycol (PEG) chain length. The magnetic MBs with PEG2000 have been chosen for targeted BP nanosheets delivery due to the better stability and magnetic responsiveness. The magnetic black phosphorus microbubbles (MBBPM) can realize the targeted tumor theranostics in vitro and in vivo. They could be applied for the targeted ultrasound imaging with an enhanced echogenicity by three times when accumulated at the target site where the magnetic field is applied. As the NIR laser irradiation was applied on the accumulated MBBPM, they dynamited and the temperature increased rapidly. It improved the cell membrane permeability, thus accelerating and enhancing a precision photothermal killing effect to the breast cancer cells, compared to BP alone.
