Nature Communications (Mar 2019)

Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density

  • Erna V. Ivarsdottir,
  • Stefania Benonisdottir,
  • Gudmar Thorleifsson,
  • Patrick Sulem,
  • Asmundur Oddsson,
  • Unnur Styrkarsdottir,
  • Snaedis Kristmundsdottir,
  • Gudny A. Arnadottir,
  • Gudmundur Thorgeirsson,
  • Ingileif Jonsdottir,
  • Gunnar M. Zoega,
  • Unnur Thorsteinsdottir,
  • Daniel F. Gudbjartsson,
  • Fridbert Jonasson,
  • Hilma Holm,
  • Kari Stefansson

DOI
https://doi.org/10.1038/s41467-019-09304-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

The corneal endothelium is crucial for proper vision. Here, Ivarsdottir et al. perform genome-wide association studies for various corneal endothelial cell measurements and find that an intergenic variant near ANAPC1 explains 24% of the variance of endothelial cell density and associates with corneal hysteresis.