Nature Communications (Aug 2019)
Population dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection
- Brian M. Forde,
- Leah W. Roberts,
- Minh-Duy Phan,
- Kate M. Peters,
- Brittany A. Fleming,
- Colin W. Russell,
- Sara M. Lenherr,
- Jeremy B. Myers,
- Adam P. Barker,
- Mark A. Fisher,
- Teik-Min Chong,
- Wai-Fong Yin,
- Kok-Gan Chan,
- Mark A. Schembri,
- Matthew A. Mulvey,
- Scott A. Beatson
Affiliations
- Brian M. Forde
- School of Chemistry and Molecular Biosciences, The University of Queensland
- Leah W. Roberts
- School of Chemistry and Molecular Biosciences, The University of Queensland
- Minh-Duy Phan
- School of Chemistry and Molecular Biosciences, The University of Queensland
- Kate M. Peters
- School of Chemistry and Molecular Biosciences, The University of Queensland
- Brittany A. Fleming
- Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine
- Colin W. Russell
- Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine
- Sara M. Lenherr
- Genitourinary Injury and Reconstructive Urology, Department of Surgery, University of Utah
- Jeremy B. Myers
- Genitourinary Injury and Reconstructive Urology, Department of Surgery, University of Utah
- Adam P. Barker
- ARUP Laboratories and Department of Pathology, University of Utah
- Mark A. Fisher
- ARUP Laboratories and Department of Pathology, University of Utah
- Teik-Min Chong
- Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya
- Wai-Fong Yin
- Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya
- Kok-Gan Chan
- Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya
- Mark A. Schembri
- School of Chemistry and Molecular Biosciences, The University of Queensland
- Matthew A. Mulvey
- Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine
- Scott A. Beatson
- School of Chemistry and Molecular Biosciences, The University of Queensland
- DOI
- https://doi.org/10.1038/s41467-019-11571-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Recurrent urinary tract infections occur in ~ 25% of women. Here, Beatson and colleagues use whole genome sequencing to track the dynamics of an E. coli ST131 clone in a single patient over a 5-year period. This study provides unique insights into pathogen evolution during recurrent urinary infection.
