mBio
(Apr 2021)
B Lymphocytes, but Not Dendritic Cells, Efficiently HIV-1
<i>Trans</i>
Infect Naive CD4
<sup>+</sup>
T Cells: Implications for the Viral Reservoir
Abigail Gerberick,
Diana C. DeLucia,
Paolo Piazza,
Mounia Alaoui-El-Azher,
Charles R. Rinaldo,
Nicolas Sluis-Cremer,
Giovanna Rappocciolo
Affiliations
Abigail Gerberick
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Diana C. DeLucia
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Paolo Piazza
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Mounia Alaoui-El-Azher
Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Charles R. Rinaldo
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Nicolas Sluis-Cremer
Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Giovanna Rappocciolo
ORCiD Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
DOI
https://doi.org/10.1128/mBio.02998-20
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
The latent human immunodeficiency virus type 1 (HIV-1) reservoir in persons on antiretroviral therapy (ART) represents a major barrier to a cure. Although most studies have focused on the HIV-1 reservoir in the memory T cell subset, replication-competent HIV-1 has been isolated from T NnegN
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