Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

Liting Yan; Liting Yan; Kaiju Xu; Kaiju Xu; Qing Xiao; Lin Tuo; Lin Tuo; Tingting Luo; Tingting Luo; Shuqiang Wang; Shuqiang Wang; Renguo Yang; Renguo Yang; Fujie Zhang; Xingxiang Yang; Xingxiang Yang

doi:10.3389/fimmu.2023.1152951

Frontiers in Immunology (May 2023)

Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

Liting Yan,
Liting Yan,
Kaiju Xu,
Kaiju Xu,
Qing Xiao,
Lin Tuo,
Lin Tuo,
Tingting Luo,
Tingting Luo,
Shuqiang Wang,
Shuqiang Wang,
Renguo Yang,
Renguo Yang,
Fujie Zhang,
Xingxiang Yang,
Xingxiang Yang

Affiliations

Liting Yan: Department of Infectious Disease, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Liting Yan: Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Kaiju Xu: Department of Infectious Disease, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Kaiju Xu: Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Qing Xiao: Clinical and Research Center for Infectious Diseases, Beijing Ditan Hospital, Beijing, China
Lin Tuo: Department of Infectious Disease, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Lin Tuo: Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Tingting Luo: Department of Infectious Disease, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Tingting Luo: Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Shuqiang Wang: Department of Infectious Disease, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Shuqiang Wang: Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Renguo Yang: Department of Infectious Disease, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Renguo Yang: Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China
Fujie Zhang: Clinical and Research Center for Infectious Diseases, Beijing Ditan Hospital, Beijing, China
Xingxiang Yang: Department of Infectious Disease, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Xingxiang Yang: Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China

DOI: https://doi.org/10.3389/fimmu.2023.1152951
Journal volume & issue: Vol. 14

Abstract

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Highly active antiretroviral therapy (ART) can effectively inhibit virus replication and restore immune function in most people living with human immunodeficiency virus (HIV). However, an important proportion of patients fail to achieve a satisfactory increase in CD4+ T cell counts. This state is called incomplete immune reconstitution or immunological nonresponse (INR). Patients with INR have an increased risk of clinical progression and higher rates of mortality. Despite widespread attention to INR, the precise mechanisms remain unclear. In this review, we will discuss the alterations in the quantity and quality of CD4+ T as well as multiple immunocytes, changes in soluble molecules and cytokines, and their relationship with INR, aimed to provide cellular and molecular insights into incomplete immune reconstitution.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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