MBLinhibitors.com, a Website Resource Offering Information and Expertise for the Continued Development of Metallo-β-Lactamase Inhibitors
Zishuo Cheng,
Caitlyn A. Thomas,
Adam R. Joyner,
Robert L. Kimble,
Aidan M. Sturgill,
Nhu-Y Tran,
Maya R. Vulcan,
Spencer A. Klinsky,
Diego J. Orea,
Cody R. Platt,
Fanpu Cao,
Bo Li,
Qilin Yang,
Cole J. Yurkiewicz,
Walter Fast,
Michael W. Crowder
Affiliations
Zishuo Cheng
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
Caitlyn A. Thomas
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
Adam R. Joyner
Department of Computer Science and Software Engineering, Miami University, Oxford, OH 45056, USA
Robert L. Kimble
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
Aidan M. Sturgill
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
Nhu-Y Tran
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
Maya R. Vulcan
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
Spencer A. Klinsky
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
Diego J. Orea
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
Cody R. Platt
Department of Computer Science and Software Engineering, Miami University, Oxford, OH 45056, USA
Fanpu Cao
Department of Computer Science and Software Engineering, Miami University, Oxford, OH 45056, USA
Bo Li
Department of Computer Science and Software Engineering, Miami University, Oxford, OH 45056, USA
Qilin Yang
Department of Computer Science and Software Engineering, Miami University, Oxford, OH 45056, USA
Cole J. Yurkiewicz
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
Walter Fast
Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy and the LaMontagne Center for Infectious Disease, University of Texas, Austin, TX 78712, USA
Michael W. Crowder
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
In an effort to facilitate the discovery of new, improved inhibitors of the metallo-β-lactamases (MBLs), a new, interactive website called MBLinhibitors.com was developed. Despite considerable efforts from the science community, there are no clinical inhibitors of the MBLs, which are now produced by human pathogens. The website, MBLinhibitors.com, contains a searchable database of known MBL inhibitors, and inhibitors can be searched by chemical name, chemical formula, chemical structure, Simplified Molecular-Input Line-Entry System (SMILES) format, and by the MBL on which studies were conducted. The site will also highlight a “MBL Inhibitor of the Month”, and researchers are invited to submit compounds for this feature. Importantly, MBLinhibitors.com was designed to encourage collaboration, and researchers are invited to submit their new compounds, using the “Submit” function on the site, as well as their expertise using the “Collaboration” function. The intention is for this site to be interactive, and the site will be improved in the future as researchers use the site and suggest improvements. It is hoped that MBLinhibitors.com will serve as the one-stop site for any important information on MBL inhibitors and will aid in the discovery of a clinically useful MBL inhibitor.
