Cancer Management and Research (Apr 2022)
CMTM Family and Gastrointestinal Tract Cancers: A Comprehensive Review
Abstract
Jie Li,1 Xiaozi Wang,2 Xiaoning Wang,1 Yan Liu,1 Na Zheng,1 Pengwei Xu,2 Xianghong Zhang,2 Liying Xue2 1Department of Hematology, Hebei General Hospital, Shijiazhuang, 050000, People’s Republic of China; 2Laboratory of Pathology, Hebei Medical University, Shijiazhuang, 050000, People’s Republic of ChinaCorrespondence: Liying Xue, Laboratory of Pathology, Hebei Medical University, No. 361, Zhongshan Eastern Road, Shijiazhuang, 050000, People’s Republic of China, Tel +86 311 86265561, Email [email protected]: Gastrointestinal tract cancers are a highly heterogeneous group of malignant diseases, contributing significantly to the burden of death worldwide. Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTMs) plays important roles in cancer development and progression. Since the first member was cloned, there have been abundant studies on the relationships between the CMTM family and human cancers. It has been reported that the CMTM family has a large potential prognostic value for multiple cancers. Meanwhile, upregulated or downregulated expression of the family members was related to advanced tumor stage, metastasis, and overall survival. Studies have also reported that these proteins play critical roles in antitumor immunity. We performed a systematic review to sum up the latest advances of CMTM family’ roles in gastrointestinal tract cancers, with a primary focus on hepatocellular carcinoma and gastric carcinoma.Keywords: CMTM family, gastrointestinal tract cancers, MARVEL, hepatocellular carcinoma, gastric carcinoma
