No predialysis treatment of blood primes in pediatric continuous kidney replacement therapy

Abstract

Abstract Background Pediatric continuous kidney replacement therapy (CKRT) uses blood as the priming fluid in the CKRT circuit to prevent hemodilution and hypotension and is dialyzed using a dialysate before the start of CKRT. This study aimed to investigate the safety of CKRT using a protocol of no predialysis after blood priming in underweight infants, based on hemodynamic and laboratory data changes. Methods This single-center retrospective cohort study included children weighing 95% of the levels before extracorporeal circulation. Moreover, potassium levels, which were not significantly different between extracorporeal circulation and dialysis initiation (p = 1.000), were significantly decreased after dialysis (p = 0.046). Lactate and hematocrit did not significantly change either before dialysis (p = 0.131 and 0.071, respectively) or after dialysis compared to the time of extracorporeal circulation (p = 1.000 and 0.591, respectively). Conclusions CKRT, using our protocol, could be safely performed without predialysis treatment of blood primes in children weighing < 5 kg.

Keywords

• Infant
• Continuous kidney replacement therapy
• Blood prime
• Priming volume
• Hypotension