Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials
Nicolas Debons,
Kenta Matsumoto,
Noriyuki Hirota,
Thibaud Coradin,
Toshiyuki Ikoma,
Carole Aimé
Affiliations
Nicolas Debons
Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Sorbonne Université, CNRS, 75005 Paris, France
Kenta Matsumoto
Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Materials Science and Engineering, Ookayama 2-12-1, Meguro-ku, Tokyo 152-8550, Japan
Noriyuki Hirota
National Institute for Materials Science, Fine Particles Engineering Group, 3-13 Sakura, Tuskuba 305-0003, Japan
Thibaud Coradin
Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Sorbonne Université, CNRS, 75005 Paris, France
Toshiyuki Ikoma
Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Materials Science and Engineering, Ookayama 2-12-1, Meguro-ku, Tokyo 152-8550, Japan
Carole Aimé
Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Sorbonne Université, CNRS, 75005 Paris, France
Major progress in the field of regenerative medicine is expected from the design of artificial scaffolds that mimic both the structural and functional properties of the ECM. The bionanocomposites approach is particularly well fitted to meet this challenge as it can combine ECM-based matrices and colloidal carriers of biological cues that regulate cell behavior. Here we have prepared bionanocomposites under high magnetic field from tilapia fish scale collagen and multifunctional silica nanoparticles (SiNPs). We show that scaffolding cues (collagen), multiple display of signaling peptides (SiNPs) and control over the global structuration (magnetic field) can be combined into a unique bionanocomposite for the engineering of biomaterials with improved cell performances.
