Biomedicines (Jan 2021)
The Biology of Vasopressin
- Samantha Sparapani,
- Cassandra Millet-Boureima,
- Joshua Oliver,
- Kathy Mu,
- Pegah Hadavi,
- Tamar Kalostian,
- Nazifa Ali,
- Carla Maria Avelar,
- Marion Bardies,
- Brenton Barrow,
- Minky Benedikt,
- Giuliana Biancardi,
- Raminder Bindra,
- Lisa Bui,
- Zakaria Chihab,
- Ashley Cossitt,
- Jeffrey Costa,
- Tina Daigneault,
- Jocelyn Dault,
- Isa Davidson,
- Jonathan Dias,
- Emie Dufour,
- Sabine El-Khoury,
- Nargess Farhangdoost,
- Anika Forget,
- Alexa Fox,
- Myriam Gebrael,
- Maria Concetta Gentile,
- Olivia Geraci,
- Ansley Gnanapragasam,
- Elias Gomah,
- Elie Haber,
- Claudia Hamel,
- Thivya Iyanker,
- Christina Kalantzis,
- Sara Kamali,
- Elsa Kassardjian,
- Hryssi Krissy Kontos,
- Thi Bich Uyen Le,
- Daniella LoScerbo,
- Yan Fang Low,
- Danielle Mac Rae,
- Flore Maurer,
- Sana Mazhar,
- Alice Nguyen,
- Kathy Nguyen-Duong,
- Chelsea Osborne-Laroche,
- Hwi Wun Park,
- Emilie Parolin,
- Kahlila Paul-Cole,
- Leah Sarah Peer,
- Margaux Philippon,
- Charles-Alexandre Plaisir,
- Jessica Porras Marroquin,
- Simran Prasad,
- Rewaparsad Ramsarun,
- Saad Razzaq,
- Samantha Rhainds,
- Damien Robin,
- Ryan Scartozzi,
- Davindra Singh,
- Sajad Soleimani Fard,
- Maxim Soroko,
- Nastaran Soroori Motlagh,
- Kiri Stern,
- Laila Toro,
- M. Wyatt Toure,
- Stephanie Tran-Huynh,
- Sarah Trépanier-Chicoine,
- Claudia Waddingham,
- Aaliyah Jasmine Weekes,
- Allison Wisniewski,
- Chiara Gamberi
Affiliations
- Samantha Sparapani
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Cassandra Millet-Boureima
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Joshua Oliver
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Kathy Mu
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Pegah Hadavi
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Tamar Kalostian
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Nazifa Ali
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Carla Maria Avelar
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Marion Bardies
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Brenton Barrow
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Minky Benedikt
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Giuliana Biancardi
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Raminder Bindra
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Lisa Bui
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Zakaria Chihab
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Ashley Cossitt
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Jeffrey Costa
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Tina Daigneault
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Jocelyn Dault
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Isa Davidson
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Jonathan Dias
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Emie Dufour
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Sabine El-Khoury
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Nargess Farhangdoost
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Anika Forget
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Alexa Fox
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Myriam Gebrael
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Maria Concetta Gentile
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Olivia Geraci
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Ansley Gnanapragasam
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Elias Gomah
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Elie Haber
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Claudia Hamel
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Thivya Iyanker
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Christina Kalantzis
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Sara Kamali
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Elsa Kassardjian
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Hryssi Krissy Kontos
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Thi Bich Uyen Le
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Daniella LoScerbo
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Yan Fang Low
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Danielle Mac Rae
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Flore Maurer
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Sana Mazhar
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Alice Nguyen
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Kathy Nguyen-Duong
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Chelsea Osborne-Laroche
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Hwi Wun Park
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Emilie Parolin
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Kahlila Paul-Cole
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Leah Sarah Peer
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Margaux Philippon
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Charles-Alexandre Plaisir
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Jessica Porras Marroquin
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Simran Prasad
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Rewaparsad Ramsarun
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Saad Razzaq
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Samantha Rhainds
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Damien Robin
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Ryan Scartozzi
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Davindra Singh
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Sajad Soleimani Fard
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Maxim Soroko
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Nastaran Soroori Motlagh
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Kiri Stern
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Laila Toro
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- M. Wyatt Toure
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Stephanie Tran-Huynh
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Sarah Trépanier-Chicoine
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Claudia Waddingham
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Aaliyah Jasmine Weekes
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Allison Wisniewski
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- Chiara Gamberi
- Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada
- DOI
- https://doi.org/10.3390/biomedicines9010089
- Journal volume & issue
-
Vol. 9,
no. 1
p. 89
Abstract
Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response. Vasopressin synthesis in several cell types, storage in intracellular vesicles, and release in response to physiological stimuli are highly regulated and mediated by three distinct G protein coupled receptors. Other receptors may bind or cross-bind vasopressin. Vasopressin is regulated spatially and temporally through transcriptional and post-transcriptional mechanisms, sex, tissue, and cell-specific receptor expression. Anomalies of vasopressin signaling have been observed in polycystic kidney disease, chronic heart failure, and neuropsychiatric conditions. Growing knowledge of the central biological roles of vasopressin has enabled pharmacological advances to treat these conditions by targeting defective systemic or central pathways utilizing specific agonists and antagonists.
Keywords
