Mediators of Inflammation (Jan 1997)

Tumour necrosis factor-alpha (TNFα) stimulates the growth of human bone marrow stromal cells

  • F. Rougier,
  • E. Cornu,
  • N. Gachard,
  • V. Praloran,
  • Y. Denizot

DOI
https://doi.org/10.1080/09629359791730
Journal volume & issue
Vol. 6, no. 3
pp. 233 – 235

Abstract

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This study reports that TNF-α is a potent mitogen for human bone marrow sternal cells in vitro (assessed by [3H]-thymidine incorporation into DNA and cell counts). In contrast, cytokines such as IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-6, LIF, SCF, M-CSF, G-CSF and GM-CSF had no effect. The effect of TNF-α on the growth of human bone marrow stromal cells could be of importance during inflammatory processes which take place in the marrow, for example marrow fibrosis.