Nature Communications (Nov 2022)

Acousto-holographic reconstruction of whole-cell stiffness maps

  • Rahmetullah Varol,
  • Zeynep Karavelioglu,
  • Sevde Omeroglu,
  • Gizem Aydemir,
  • Aslihan Karadag,
  • Hanife E. Meco,
  • Ali A. Demircali,
  • Abdurrahim Yilmaz,
  • Gizem C. Kocal,
  • Gulsum Gencoglan,
  • Muhammed E. Oruc,
  • Gokhan B. Esmer,
  • Yasemin Basbinar,
  • Sahin K. Ozdemir,
  • Huseyin Uvet

DOI
https://doi.org/10.1038/s41467-022-35075-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 10

Abstract

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Traditional methods for cell stiffness measurements are limited by long processing times and unsuitability for multiple cell analysis. Here, the authors demonstrate a fast technique based on acoustic stimulation and holographic imaging to reconstruct whole-cell stiffness maps of individual and multiple cells.