Communications Biology (Oct 2022)

Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle

  • Nirajan Neupane,
  • Jayasimman Rajendran,
  • Jouni Kvist,
  • Sandra Harjuhaahto,
  • Bowen Hu,
  • Veijo Kinnunen,
  • Yang Yang,
  • Anni I. Nieminen,
  • Henna Tyynismaa

DOI
https://doi.org/10.1038/s42003-022-04034-z
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 12

Abstract

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Muscular pathologies, including muscular dystrophy, are caused by a number of cellular and metabolic perturbations; here, consequences of GRPEL1-null disrupted mitochondrial matrix protein import on muscle atrophy, metabolism, and stress responses are examined.