Nature Communications (Dec 2021)

Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

  • Catherine S. Storm,
  • Demis A. Kia,
  • Mona M. Almramhi,
  • Sara Bandres-Ciga,
  • Chris Finan,
  • International Parkinson’s Disease Genomics Consortium (IPDGC),
  • Aroon D. Hingorani,
  • Nicholas W. Wood

DOI
https://doi.org/10.1038/s41467-021-26280-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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There is currently no disease-modifying treatment for Parkinson’s disease, a common neurodegenerative disorder. Here, the authors use genetic variation associated with gene and protein expression to find putative drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome.