Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

Huixin Xu; Ryann M. Fame; Cameron Sadegh; Jason Sutin; Christopher Naranjo; Della Syau; Jin Cui; Frederick B. Shipley; Amanda Vernon; Fan Gao; Yong Zhang; Michael J. Holtzman; Myriam Heiman; Benjamin C. Warf; Pei-Yi Lin; Maria K. Lehtinen

doi:10.1038/s41467-020-20666-3

Nature Communications (Jan 2021)

Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

Huixin Xu,
Ryann M. Fame,
Cameron Sadegh,
Jason Sutin,
Christopher Naranjo,
Della Syau,
Jin Cui,
Frederick B. Shipley,
Amanda Vernon,
Fan Gao,
Yong Zhang,
Michael J. Holtzman,
Myriam Heiman,
Benjamin C. Warf,
Pei-Yi Lin,
Maria K. Lehtinen

Affiliations

Huixin Xu: Department of Pathology, Boston Children’s Hospital
Ryann M. Fame: Department of Pathology, Boston Children’s Hospital
Cameron Sadegh: Department of Pathology, Boston Children’s Hospital
Jason Sutin: Fetal-Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School
Christopher Naranjo: Summer Honors Undergraduate Research Program, Division of Medical Sciences, Harvard Medical School
Della Syau: Summer Honors Undergraduate Research Program, Division of Medical Sciences, Harvard Medical School
Jin Cui: Department of Pathology, Boston Children’s Hospital
Frederick B. Shipley: Department of Pathology, Boston Children’s Hospital
Amanda Vernon: Broad Institute of MIT and Harvard
Fan Gao: Broad Institute of MIT and Harvard
Yong Zhang: Pulmonary and Critical Care Medicine, Department of Medicine, Washington University
Michael J. Holtzman: Pulmonary and Critical Care Medicine, Department of Medicine, Washington University
Myriam Heiman: Broad Institute of MIT and Harvard
Benjamin C. Warf: Department of Neurosurgery, Boston Children’s Hospital
Pei-Yi Lin: Fetal-Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School
Maria K. Lehtinen: Department of Pathology, Boston Children’s Hospital

DOI: https://doi.org/10.1038/s41467-020-20666-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Abnormal CSF accumulation in the brain can lead to hydrocephalus. The mechanisms regulating CSF clearance during early development are unclear. Here, the authors show that NKCC1 regulates the clearance of both CSF K+ and fluid volume through the choroid plexus during postnatal development in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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