The Association Analysis of Immune System Genes Allelic Variants With Embryonic Infection of Newborns

Abstract

To investigate the association of marker genes and their polymorphisms with increased risk of embryonic infection (EI)- of the fetus and of the nervous system lesions development of different severity. Methods: The TLR2, TLR6, IL1ß, TNFa, IL10 genotypes and alleles frequencies were studied in three groups of infants of Rostov region with EI followed by hypoxic lesions of the central nervous system. Results: In our study the allelic variants of IL1ß and TNFa genes are characterized by a high level of expression, while the allelic variant of the IL10 gene results in a decrease in the corresponding mRNA level. Conclusion: The importance of the Ser249Pro (TLR6), -308G/A (TNFa) and -31C/T (IL1ß) interactions in changing the risk of the EI development was established

Keywords

• Embryonic infection
• Central nervous system (CNS) abnormalities
• TLR 2
• TLR 6
• IL 1ß
• TNF a
• IL10
• Polymorphism.