Nature Communications (Jan 2020)
MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
- Yota Yasumizu,
- Hasan Rajabi,
- Caining Jin,
- Tsuyoshi Hata,
- Sean Pitroda,
- Mark D. Long,
- Masayuki Hagiwara,
- Wei Li,
- Qiang Hu,
- Song Liu,
- Nami Yamashita,
- Atsushi Fushimi,
- Ling Kui,
- Mehmet Samur,
- Masaaki Yamamoto,
- Yan Zhang,
- Ning Zhang,
- Deli Hong,
- Takahiro Maeda,
- Takeo Kosaka,
- Kwok K. Wong,
- Mototsugu Oya,
- Donald Kufe
Affiliations
- Yota Yasumizu
- Dana-Farber Cancer Institute Harvard Medical School
- Hasan Rajabi
- Dana-Farber Cancer Institute Harvard Medical School
- Caining Jin
- Dana-Farber Cancer Institute Harvard Medical School
- Tsuyoshi Hata
- Dana-Farber Cancer Institute Harvard Medical School
- Sean Pitroda
- Department of Radiation and Cellular Oncology, University of Chicago
- Mark D. Long
- Department of Biostatistics and Bioinformatics Roswell Park Comprehensive Cancer Center
- Masayuki Hagiwara
- Dana-Farber Cancer Institute Harvard Medical School
- Wei Li
- Dana-Farber Cancer Institute Harvard Medical School
- Qiang Hu
- Department of Biostatistics and Bioinformatics Roswell Park Comprehensive Cancer Center
- Song Liu
- Department of Biostatistics and Bioinformatics Roswell Park Comprehensive Cancer Center
- Nami Yamashita
- Dana-Farber Cancer Institute Harvard Medical School
- Atsushi Fushimi
- Dana-Farber Cancer Institute Harvard Medical School
- Ling Kui
- Dana-Farber Cancer Institute Harvard Medical School
- Mehmet Samur
- Dana-Farber Cancer Institute Harvard Medical School
- Masaaki Yamamoto
- Dana-Farber Cancer Institute Harvard Medical School
- Yan Zhang
- Dana-Farber Cancer Institute Harvard Medical School
- Ning Zhang
- Dana-Farber Cancer Institute Harvard Medical School
- Deli Hong
- Dana-Farber Cancer Institute Harvard Medical School
- Takahiro Maeda
- Department of Urology, Keio University School of Medicine Shinjuku-ku
- Takeo Kosaka
- Department of Urology, Keio University School of Medicine Shinjuku-ku
- Kwok K. Wong
- Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center
- Mototsugu Oya
- Department of Urology, Keio University School of Medicine Shinjuku-ku
- Donald Kufe
- Dana-Farber Cancer Institute Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-14219-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
MUC1-C is overexpressed in castration-resistant prostate cancer and neuroendocrine prostate cancer. Here, the authors show that MUC1-C drives lineage plasticity through MYC and BRN2, inducing neuroendocrine features and stemness in prostate cancer.
