Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ (Mar 2015)

THE SYNTHESIS OF RGDF MIMETIC DERIVATIVES BASED ON 4-(ISOINDOLINE-5-YL)AMINO-4-OXOBUTYRIC ACID WITH THE ORAL ANTIAGGREGATIVE ACTIVITY

  • A. A. Krysko,
  • B. M. Chugunov,
  • S. A. Andronati,
  • T. A. Kabanova,
  • I. M. Rakipov,
  • A. V. Mazepa

DOI
https://doi.org/10.18524/2304-0947.2010.2.40109
Journal volume & issue
Vol. 15, no. 2
pp. 60 – 68

Abstract

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Ethyl ethers of N-[4-(isoindoline-5-yl)amino-4-oxobutyryl]-D,L-β-substituted-β-alanines were synthesized. Estimation of antiaggregatory activity of the compounds obtained has showed that the compounds possess an oral activity ex vivoin mice with the use of human rich platelet plasma.

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