Clinical features and endoscopic findings of pituicytoma in the sellar region: A case report and review of the literature

Tomoharu Aki, MD; Akihiro Inoue, MD, PhD; Shohei Kohno, MD, PhD; Naoya Nishida, MD, PhD; Shin Yamashita, MD, PhD; Mana Fukushima, MD, PhD; Shirabe Matsumoto, MD, PhD; Satoshi Suehiro, MD, PhD; Masahiro Nishikawa, MD; Saya Ozaki, MD; Seiji Shigekawa, MD, PhD; Hideaki Watanabe, MD, PhD; Riko Kitazawa, MD, PhD; Takeharu Kunieda, MD, PhD

Interdisciplinary Neurosurgery (Jun 2019)

Clinical features and endoscopic findings of pituicytoma in the sellar region: A case report and review of the literature

Tomoharu Aki, MD,
Akihiro Inoue, MD, PhD,
Shohei Kohno, MD, PhD,
Naoya Nishida, MD, PhD,
Shin Yamashita, MD, PhD,
Mana Fukushima, MD, PhD,
Shirabe Matsumoto, MD, PhD,
Satoshi Suehiro, MD, PhD,
Masahiro Nishikawa, MD,
Saya Ozaki, MD,
Seiji Shigekawa, MD, PhD,
Hideaki Watanabe, MD, PhD,
Riko Kitazawa, MD, PhD,
Takeharu Kunieda, MD, PhD

Affiliations

Tomoharu Aki, MD: Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Akihiro Inoue, MD, PhD: Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan; Corresponding author at: Department of Neurosurgery, Ehime University School of Medicine, 495 Shitsukawa, Toon, Ehime 791-0295, Japan.
Shohei Kohno, MD, PhD: Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Naoya Nishida, MD, PhD: Departments of Otolaryngology, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Shin Yamashita, MD, PhD: Departments of Gastroenterology and Metabology, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Mana Fukushima, MD, PhD: Division of Diagnostic Pathology, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Shirabe Matsumoto, MD, PhD: Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Satoshi Suehiro, MD, PhD: Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Masahiro Nishikawa, MD: Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Saya Ozaki, MD: Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Seiji Shigekawa, MD, PhD: Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Hideaki Watanabe, MD, PhD: Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Riko Kitazawa, MD, PhD: Division of Diagnostic Pathology, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime 791-0295, Japan
Takeharu Kunieda, MD, PhD: Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan

Journal volume & issue: Vol. 16
pp. 58 – 61

Abstract

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We report a rare case of pituicytoma occurring in the sellar region resected by endoscopic transsphenoidal surgery (ETSS). We suggest useful indicators for the accurate diagnosis and pitfalls for the surgical procedure. A 38-year-old man was admitted to our hospital with polyuria, erectile dysfunction and bitemporal hemianopsia. Neuroimaging revealed pituitary tumor in the sellar region, and the enhanced anterior pituitary gland was displaced anteriorly. Gross total resection was achieved using ETSS. Histological findings revealed bipolar spindle cells staining strongly for thyroid transcription factor 1 (TTF-1). We diagnosed the tumor as pituicytoma originated from posterior pituitary. Pituicytoma is difficult to diagnose on routine neuroimaging and pathological analysis, so accurate diagnosis requires identification of the forward deviation of anterior pituitary gland and analysis of immunohistochemical studies using TTF-1. Keywords: Pituicytoma, Forward deviation of anterior pituitary lobe, Thyroid transcription factor 1

Published in Interdisciplinary Neurosurgery

ISSN: 2214-7519 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Surgery; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/interdisciplinary-neurosurgery/

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