The Role of Branched-Chain Amino Acids and Branched-Chain α-Keto Acid Dehydrogenase Kinase in Metabolic Disorders

Chuang Du; Chuang Du; Chuang Du; Chuang Du; Wen-Jie Liu; Wen-Jie Liu; Wen-Jie Liu; Jing Yang; Jing Yang; Jing Yang; Shan-Shan Zhao; Shan-Shan Zhao; Shan-Shan Zhao; Shan-Shan Zhao; Hui-Xin Liu; Hui-Xin Liu; Hui-Xin Liu

doi:10.3389/fnut.2022.932670

Frontiers in Nutrition (Jul 2022)

The Role of Branched-Chain Amino Acids and Branched-Chain α-Keto Acid Dehydrogenase Kinase in Metabolic Disorders

Chuang Du,
Chuang Du,
Chuang Du,
Chuang Du,
Wen-Jie Liu,
Wen-Jie Liu,
Wen-Jie Liu,
Jing Yang,
Jing Yang,
Jing Yang,
Shan-Shan Zhao,
Shan-Shan Zhao,
Shan-Shan Zhao,
Shan-Shan Zhao,
Hui-Xin Liu,
Hui-Xin Liu,
Hui-Xin Liu

Affiliations

Chuang Du: Institute of Life Sciences, China Medical University, Shenyang, China
Chuang Du: Health Sciences Institute, China Medical University, Shenyang, China
Chuang Du: Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, China
Chuang Du: Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, China
Wen-Jie Liu: Institute of Life Sciences, China Medical University, Shenyang, China
Wen-Jie Liu: Health Sciences Institute, China Medical University, Shenyang, China
Wen-Jie Liu: Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, China
Jing Yang: Institute of Life Sciences, China Medical University, Shenyang, China
Jing Yang: Health Sciences Institute, China Medical University, Shenyang, China
Jing Yang: Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, China
Shan-Shan Zhao: Institute of Life Sciences, China Medical University, Shenyang, China
Shan-Shan Zhao: Health Sciences Institute, China Medical University, Shenyang, China
Shan-Shan Zhao: Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, China
Shan-Shan Zhao: Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China
Hui-Xin Liu: Institute of Life Sciences, China Medical University, Shenyang, China
Hui-Xin Liu: Health Sciences Institute, China Medical University, Shenyang, China
Hui-Xin Liu: Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, China

DOI: https://doi.org/10.3389/fnut.2022.932670
Journal volume & issue: Vol. 9

Abstract

Read online

Branched-chain amino acids (BCAAs), composed of leucine, isoleucine, and valine, are important essential amino acids in human physiology. Decades of studies have revealed their roles in protein synthesis, regulating neurotransmitter synthesis, and the mechanistic target of rapamycin (mTOR). BCAAs are found to be related to many metabolic disorders, such as insulin resistance, obesity, and heart failure. Also, many diseases are related to the alteration of the BCAA catabolism enzyme branched-chain α-keto acid dehydrogenase kinase (BCKDK), including maple syrup urine disease, human autism with epilepsy, and so on. In this review, diseases and the corresponding therapies are discussed after the introduction of the catabolism and detection methods of BCAAs and BCKDK. Also, the interaction between microbiota and BCAAs is highlighted.

Published in Frontiers in Nutrition

ISSN: 2296-861X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.frontiersin.org/journals/nutrition/

About the journal

Abstract

Keywords