Mitochondrial superoxide dismutase 2 mediates γ-irradiation-induced cancer cell invasion

Abstract

Cancer treatment: Stopping the spread after radiotherapy A drug usually used to treat type 2 diabetes may also help to prevent cancer relapse following radiotherapy, which is commonly used to kill cancer cells. However, any tumor cells that survive radiation are highly invasive, sometimes causing tumors to spread. Hong-Duck Um and co-workers at the Korea Institute of Radiological & Medical Sciences in Seoul, South Korea, noticed that the surviving cells often showed higher levels of a key enzyme, superoxide dismutase 2 (SOD2), which is involved in energy production in the cellular powerhouse, the mitochondria. Artificially increasing levels of SOD2, without radiation, made cells more invasive. Treatment with metformin, which prevents production of the molecule that SOD2 acts on, prevented cells from becoming invasive. SOD2 has been implicated in many cancers, and is therefore a very promising therapeutic target.