Journal of Clinical Medicine (Sep 2022)
Prevalence and Risk Factor Analysis of Post-Intensive Care Syndrome in Patients with COVID-19 Requiring Mechanical Ventilation: A Multicenter Prospective Observational Study
- Junji Hatakeyama,
- Shigeaki Inoue,
- Keibun Liu,
- Kazuma Yamakawa,
- Takeshi Nishida,
- Shinichiro Ohshimo,
- Satoru Hashimoto,
- Naoki Kanda,
- Shuhei Maruyama,
- Yoshitaka Ogata,
- Daisuke Kawakami,
- Hiroaki Shimizu,
- Katsura Hayakawa,
- Aiko Tanaka,
- Taku Oshima,
- Tatsuya Fuchigami,
- Hironori Yawata,
- Kyoji Oe,
- Akira Kawauchi,
- Hidehiro Yamagata,
- Masahiro Harada,
- Yuichi Sato,
- Tomoyuki Nakamura,
- Kei Sugiki,
- Takahiro Hakozaki,
- Satoru Beppu,
- Masaki Anraku,
- Noboru Kato,
- Tomomi Iwashita,
- Hiroshi Kamijo,
- Yuichiro Kitagawa,
- Michio Nagashima,
- Hirona Nishimaki,
- Kentaro Tokuda,
- Osamu Nishida,
- Kensuke Nakamura
Affiliations
- Junji Hatakeyama
- Department of Emergency and Critical Care Medicine, National Hospital Organization Tokyo Medical Center, Tokyo 152-8902, Japan
- Shigeaki Inoue
- Department of Disaster and Emergency Medicine, School of Medicine, Kobe University, Kobe 650-0017, Japan
- Keibun Liu
- Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD 4032, Australia
- Kazuma Yamakawa
- Department of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan
- Takeshi Nishida
- Division of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka 558-8558, Japan
- Shinichiro Ohshimo
- Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan
- Satoru Hashimoto
- Department of Intensive Care Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
- Naoki Kanda
- Division of General Internal Medicine, Jichi Medical University Hospital, Tochigi 329-0498, Japan
- Shuhei Maruyama
- Department of Emergency and Critical Care Medicine, Kansai Medical University Medical Center, Osaka 570-8507, Japan
- Yoshitaka Ogata
- Department of Critical Care Medicine, Yao Tokushukai General Hospital, Osaka 581-0011, Japan
- Daisuke Kawakami
- Department of Anesthesia and Critical Care, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan
- Hiroaki Shimizu
- Acute Care Medical Center, Hyogo Prefectural Kakogawa Medical Center, Kakogawa 675-8555, Japan
- Katsura Hayakawa
- Department of Emergency and Critical Care Medicine, Saitama Red Cross Hospital, Saitama 330-8553, Japan
- Aiko Tanaka
- Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
- Taku Oshima
- Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan
- Tatsuya Fuchigami
- Intensive Care Unit, University of the Ryukyus Hospital, Nishihara 903-0215, Japan
- Hironori Yawata
- Department of Emergency and Critical Care Medicine, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto 605-0981, Japan
- Kyoji Oe
- Department of Intensive Care Medicine, Asahi General Hospital, Chiba 289-2511, Japan
- Akira Kawauchi
- Japanese Red Cross Maebashi Hospital, Advanced Medical Emergency Department and Critical Care Center, Maebashi 371-0811, Japan
- Hidehiro Yamagata
- Advanced Critical Care and Emergency Center, Yokohama City University Medical Center, Yokohama 232-0024, Japan
- Masahiro Harada
- Department of Emergency and Critical Care, National Hospital Organization Kumamoto Medical Center, Kumamoto 860-0008, Japan
- Yuichi Sato
- Critical Care and Emergency Center, Metropolitan Tama General Medical Center, Tokyo 183-8524, Japan
- Tomoyuki Nakamura
- Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Nagoya 470-1192, Japan
- Kei Sugiki
- Department of Intensive Care Medicine, Yokohama City Minato Red Cross Hospital, Yokohama 231-8682, Japan
- Takahiro Hakozaki
- Department of Anesthesiology, Fukushima Medical University, Fukushima 960-1295, Japan
- Satoru Beppu
- Department of Emergency and Critical Care Medicine, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan
- Masaki Anraku
- Department of Thoracic Surgery, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173-0015, Japan
- Noboru Kato
- Department of Emergency and Critical Care Medicine, Yodogawa Christian Hospital, Osaka 533-0024, Japan
- Tomomi Iwashita
- Department of Emergency and Critical Care Center, Nagano Red Cross Hospital, Nagano 380-8582, Japan
- Hiroshi Kamijo
- Department of Emergency and Critical Care Medicine, Shinshu University Hospital, Nagano 390-8621, Japan
- Yuichiro Kitagawa
- Emergency and Disaster Medicine, Gifu University School of Medicine Graduate School of Medicine, Gifu 501-1194, Japan
- Michio Nagashima
- Department of Intensive Care Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
- Hirona Nishimaki
- Department of Anesthesiology, Tohoku University Hospital, Sendai 980-8574, Japan
- Kentaro Tokuda
- Intensive Care Unit, Kyushu University Hospital, Fukuoka 812-8582, Japan
- Osamu Nishida
- Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Nagoya 470-1192, Japan
- Kensuke Nakamura
- Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi 317-0077, Japan
- DOI
- https://doi.org/10.3390/jcm11195758
- Journal volume & issue
-
Vol. 11,
no. 19
p. 5758
Abstract
Introduction: Post-intensive care syndrome (PICS) is an emerging problem in critically ill patients and the prevalence and risk factors are unclear in patients with severe coronavirus disease 2019 (COVID-19). This multicenter prospective observational study aimed to investigate the prevalence and risk factors of PICS in ventilated patients with COVID-19 after ICU discharge. Methods: Questionnaires were administered twice in surviving patients with COVID-19 who had required mechanical ventilation, concerning Barthel Index, Short-Memory Questionnaire, and Hospital Anxiety and Depression Scale scores. The risk factors for PICS were examined using a multivariate logistic regression analysis. Results: The first and second PICS surveys were obtained at 5.5 and 13.5 months (mean) after ICU discharge, with 251 and 209 patients completing the questionnaires and with a prevalence of PICS of 58.6% and 60.8%, respectively, along with the highest percentages of cognitive impairment. Delirium (with an odds ratio of (OR) 2.34, 95% CI 1.1–4.9, and p = 0.03) and the duration of mechanical ventilation (with an OR of 1.29, 95% CI 1.05–1.58, and p = 0.02) were independently identified as the risk factors for PICS in the first PICS survey. Conclusion: Approximately 60% of the ventilated patients with COVID-19 experienced persistent PICS, especially delirium, and required longer mechanical ventilation.
Keywords