Frontiers in Synaptic Neuroscience (Nov 2018)
The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus
- Pojeong Park,
- Pojeong Park,
- Pojeong Park,
- Pojeong Park,
- Heather Kang,
- Heather Kang,
- Heather Kang,
- Thomas M. Sanderson,
- Thomas M. Sanderson,
- Zuner A. Bortolotto,
- John Georgiou,
- Min Zhuo,
- Min Zhuo,
- Bong-Kiun Kaang,
- Graham L. Collingridge,
- Graham L. Collingridge,
- Graham L. Collingridge,
- Graham L. Collingridge
Affiliations
- Pojeong Park
- Department of Biological Sciences and Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea
- Pojeong Park
- Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
- Pojeong Park
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
- Pojeong Park
- Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom
- Heather Kang
- Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
- Heather Kang
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
- Heather Kang
- Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom
- Thomas M. Sanderson
- Department of Biological Sciences and Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea
- Thomas M. Sanderson
- Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom
- Zuner A. Bortolotto
- Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom
- John Georgiou
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
- Min Zhuo
- Department of Biological Sciences and Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea
- Min Zhuo
- Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
- Bong-Kiun Kaang
- Department of Biological Sciences and Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea
- Graham L. Collingridge
- Department of Biological Sciences and Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea
- Graham L. Collingridge
- Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
- Graham L. Collingridge
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
- Graham L. Collingridge
- Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom
- DOI
- https://doi.org/10.3389/fnsyn.2018.00042
- Journal volume & issue
-
Vol. 10
Abstract
Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the protein kinase A (PKA)- and protein synthesis-dependent component of LTP.
Keywords
