Nature Communications (Dec 2021)

A d-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR

  • Dan Xiao,
  • Wen Zhang,
  • Xiaoting Guo,
  • Yidong Liu,
  • Chunxia Hu,
  • Shiting Guo,
  • Zhaoqi Kang,
  • Xianzhi Xu,
  • Cuiqing Ma,
  • Chao Gao,
  • Ping Xu

DOI
https://doi.org/10.1038/s41467-021-27357-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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d-2-hydroxyglutarate (d-2-HG) is a metabolite that can be aberrantly accumulated and acts as a biomarker in many cancers. Here the authors report a d-2-HG biosensor based on the allosteric transcription factor DhdR which they use for detection in serum and urine.