NIVOLUMAB EXPERIENCE IN PEDIATRIC MALIGNITIES

Abstract

Objective: Nivolumab is a human monoclonal antibody to programmed cell death receptor 1 (PD-1) that acts as an immune checkpoint inhibitor and is used in the immunotherapy of various types of advanced or metastatic cancer. The aim of this study is to evaluate the efficacy of nivolumab in pediatric patients with various highly malignant tumors and to share the experience of Ankara University Pediatric Oncology Department. Methodology: Eight patients were included in the study. Median age at diagnosis is 11.3 years (min 4.9- max 13.9). Treatment indications were malignant mesothelioma (1), rectal adenocarcinoma (1), malignant melanoma (1), ewing sarcoma (2), osteosarcoma (1), non-hodgkin lymphoma (1) and hodgkin lymphoma (1). Results: Four patients died due to progressive disease. Complete remission was achieved in four patients diagnosed with malignant mesothelioma, rectal adenocarcinoma, malignant melanoma and Hodgkin lymphoma. Conclusion: Immune checkpoint inhibitors are one of the greatest advances in oncological therapy and improve the overall survival of patients with advanced and resistant malignancies. More studies are needed to evaluate the efficacy of immune checkpoint inhibitors in pediatric tumors.