Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology

Youqi Tao; Yunpeng Sun; Shiran Lv; Wencheng Xia; Kun Zhao; Qianhui Xu; Qinyue Zhao; Lin He; Weidong Le; Yong Wang; Cong Liu; Dan Li

doi:10.1038/s41467-022-31790-7

Nature Communications (Jul 2022)

Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology

Youqi Tao,
Yunpeng Sun,
Shiran Lv,
Wencheng Xia,
Kun Zhao,
Qianhui Xu,
Qinyue Zhao,
Lin He,
Weidong Le,
Yong Wang,
Cong Liu,
Dan Li

Affiliations

Youqi Tao: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
Yunpeng Sun: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Shiran Lv: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Wencheng Xia: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Kun Zhao: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Qianhui Xu: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Qinyue Zhao: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
Lin He: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
Weidong Le: Institute of Neurology, Sichuan Academy of Medical Sciences-Sichuan Provincial Hospital
Yong Wang: College of Life Sciences, Institute of Quantitative Biology, Zhejiang University
Cong Liu: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Dan Li: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s41467-022-31790-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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The Cryo-EM structures reported in this work reveal how heparin incorporates into α-syn fibril formation to determine fibril polymorphs. This highlights the role of biological polymers in the conformational selection and neuropathological regulation of amyloid fibrils.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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